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S2(R1)Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use. 2011 2. ICH. M3 (R2): Non-clinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals. 2009 3.FDA. Guidance for industry and review staff: Recommended approaches to integration of genetic toxicology study results. 2006 4.OECD. Guideline for testing of chemicals No.471 Bacterial reverse mutation test.1997 5.OECD. Guideline for testing of chemicals No.473In Vitro mammalian chromosomal aberration test. 2016 6.OECD. Guideline for testing of chemicals No.474Mammalian erythrocyte micronucleus test. 2016 7.OECD. Guideline for testing of chemicals No. 475Mammalian bone marrow chromosome aberration test. 2016 8.OECD. Guideline for testing of chemicals No. 476: In vitro mammalian cell gene mutation tests using the Hprt and xprt genes. 2016 9.OECD. Guideline for testing of chemicals No. 487In vitro mammalian cell micronucleus test. 2016 10.OECD. Guideline for testing of chemicals No. 488Transgenic rodent somatic and germ cell gene mutation assays. 2013 11.OECD. Guideline for testing of chemicals No. 489In vivo mammalian alkaline comet assay. 2016 12.OECD. 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